Adult stem cells for the heart

Your message to the editors. Heart muscle cells are shown in green. Many researchers are exploring stem cell therapies as a way to supply the damaged area with functional cardiomyocytes that can replace the scarred tissue with healthy beating tissue. In addition, the human experience differs from animal models in that stem cell administration has been performed almost exclusively using intracoronary administration, while most pre-clinical models have employed intramyocardial injection. Interdisciplinary Stem Cell Institute. Scar tissue is shown in red.
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A sobering conclusion: Adult hearts contain no stem cells

This document is subject to copyright. For this reason, quality, efficacy and safety for the application in human beings have to be proven before putting such a product on the market. These stem cells have never been anywhere near an embryo. All of our testing in humans is performed with the approval of the United States Food and Drug Administration. C ardiac stem cell research has a turbulent history.
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Adult Stem Cell Research at Children’s « Boston Children's Hospital

Depending on the particular class of stem cells they have the potential to reproduce all cells of the body or only defined cell types. The heart is hardly able to regenerate or to repair the damaged tissue by itself. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. Unlike embryonic and induced pluripotent stem cells, ASCs do not pose a threat to form teratomas, nor do they have immune system concerns, making them ideal for therapeutic use in humans. Part of the heart wall of the murine heart after myocardial infarction. A group at the University of Washington recently demonstrated the potential of cardiomyocytes grown from stem cells to replace diseased heart muscle. Aside from a heart transplant there are currently no treatments which can restore heart function.
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According to the World Health Organization, ischemic heart disease is the number one cause of death in men and women worldwide, far surpassing cancers and infectious diseases. Getting these cardiomyocytes to mature properly and meet the energy demands that the heart experiences after birth, however, has proven very difficult. Scientists are working to generate cardiomyocytes in the lab that more closely mimic cells in the adult heart. Researchers at the Interdisciplinary Stem Cell Institute are working together not only on finding treatments for heart failure, but also for cancer, diabetes, bone and neurodegenerative diseases. Although the frequency and extent of myocardial renewal varies among studies, the common observation that a small fraction of myocytes contain chromosomes of host origin points to the existence of stem-cell-mediated innate myocardial regenerative capacity in humans.
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